Supratentorial recurrences in medulloblastoma

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چکیده

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Supratentorial metastasis of medulloblastoma in adults

Two adults, 31 and 20 years of age, developed supratentorial metastasis 3½ years and 11 months, respectively, after gross total removal of their posterior fossa medulloblastoma. The first case developed spinal metastasis as well. Both had undergone craniospinal irradiation. Case 1 underwent laminectomy and case 2 underwent craniotomy because their presenting symptoms required so.

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Medulloblastoma is a common pediatric tumor typically diagnosed before the age of fifteen. Initial therapy includes surgical resection and radiation of the entire neuro-axis. Recurrence is common and typically occurs within 2 years of initial diagnosis. Those fitting Collin's Law is considered tumor-free. We report a case of single supratentorial recurrence 13 years after initial diagnosis. Her...

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1.1.1 definition Medulloblastoma is a highly cellular malignant embryonal neoplasm classified as a Primitive Neuroectodermal Tumour (PNET) (Kleihues 1993). It is the most common malignant brain tumour in childhood, accounting for between 15 and 25 % of all childhood primary central nervous system (CNS) neoplasms (Peris-Bonet 2006). By definition, medulloblastoma arises in the posterior fossa, u...

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ژورنال

عنوان ژورنال: Cancer

سال: 1981

ISSN: 0008-543X,1097-0142

DOI: 10.1002/1097-0142(19810215)47:4<806::aid-cncr2820470429>3.0.co;2-p